So I've been doing a lot of thinking on this, and I think I have more detailed thoughts.
Across the board, I'm thinking sci-fi setting. But the kind of sci fi would be very different.
Hailee Steinfeld - I want her in a game very much in the vein of Mass Effect. Youngest first officer in the fleet. Over confident toa fault, doesn't recognize her own arrogance, but with a soft side as well. She's not intentionally mean or callous, her brain works faster than her heart. Lead or love interest works fine.
Also for Hailee, is there was ever a Spider-Gwen game....might as well bring her in from Spider-Verse. Also wouldn't object to her being Batgirl.
Liz Gillies - Noir Femme Fatale all the way. Either classical noir or Cyberpunk, Blade Runner style. Bioware style gameplay over the LA Noir kind. Your PI can choose to bed her or the Girl Friday of the game.
Again, maybe a step into super-heroics. If there's ever a new Batman game, I think Liz would be a spectacular Catwoman. Maybe Lois Lane for Superman. Or on her own, Zatanna.
Selena Gomez - Medical head/science officer on a star ship. A bit naive, not necessarily the best for field work. Another love interest on the ship.
Another one for the realm of super heroes, I'd say she could be another candidate for Catwoman. Maybe Jessica Cruz in a Green Lantern game...perhaps even Star Sapphire.